Antiepileptic effects of levetiracetam in a rodent neonatal seizure model
نویسندگان
چکیده
منابع مشابه
Antiepileptic effects of quinine in the pentylenetetrazole model of seizure
Quinine, is an anti-malarial drug that specifically blocks connexin 36 (Cx36) at gap junction channels. Quinine has suppressed ictal epileptiform activity in vitro without decreasing neuronal excitability. Thus, we considered the possible anticonvulsant effects of quinine in the pentylenetetrazole (PTZ) model of seizure. Moreover, we studied the hypnotic effect and locomotor activity of quinine...
متن کاملEffect of Various Antiepileptic Drugs in Zebrafish PTZ-Seizure Model
Recently zebrafish larvae have emerged as a high-throughput model for screening pharmacological activities. The present study was undertaken to investigate the effect of established anticonvulsants, such as valproic acid, carbamazepine, gabapentin, diazepam, lacosamide and pregabalin against pentylenetetrazole (6 mM) seizures in adult zebrafish. Different phases of seizures (increase swim activ...
متن کاملAntiepileptic natural product discovery using a zebrafish seizure model
helping me to resolve the questions I had. Our meetings, sometimes together with Peter, were always very constructive and taught me to evaluate my results critically. día! Angela thank you for doing some microinjections for me and the nice times together! Tatiana, thanks for the nice collaboration on the AEDs-PTZ paper and all the EEG data. Olivia thank you for proofreading this manuscript. San...
متن کاملCan pentylenetetrazole and maximal electroshock rodent seizure models quantitatively predict antiepileptic efficacy in humans?
PURPOSE Pentylenetetrazole and maximal electroshock rodent seizure models are commonly used to detect antiepileptic efficacy in drug development. The aim of this research was to evaluate the predictive capabilities of pentylenetetrazole and maximal electroshock models in estimating human exposures required for antiepileptic efficacy through a survey of current literature. METHODS A literature...
متن کاملLow risk of seizure recurrence after early withdrawal of antiepileptic treatment in the neonatal period.
The risk of seizure recurrence within the first year of life was evaluated in infants with neonatal seizures diagnosed with a combination of clinical signs, amplitude-integrated electroencephalogram (EEG) monitoring, and standard EEG. Fifty eight of 283 (4.5%) neonates in tertiary level neonatal intensive care had seizures. The mortality in the infants with neonatal seizures was 36.2%. In 31 su...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 2012
ISSN: 0031-3998,1530-0447
DOI: 10.1038/pr.2012.151